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6. 黑白箱實(shí)驗(yàn)（light dark box）

  The subject is placed in the dark portion of the box for a set period of acclimation time.  At the end of this period, a door separating the two compartments is opened.  The amount of time that the subject takes to emerge fully from the enclosed area into the open area is measured.

7. 社交行為實(shí)驗(yàn)（social interaction）

  The subject is habituated to the test chamber and allowed to freely explore for a set time.   A novel animal is placed in one of the two enclosures, and the percentage of time the mouse spends in the section with the novel animal is compared to the time spent in the section with the empty enclosure.   In a later session, the time spent with the same animal might be compared to time spent with a newer, more novel animal.

8. 條件性位置偏愛(ài)（Conditioned Place Preference）

   條件性位置偏愛(ài)實(shí)驗(yàn)（Conditioned Place Preference, CPP）實(shí)驗(yàn)是目前評(píng)價(jià)藥物精神依賴(lài)性的經(jīng)典實(shí)驗(yàn)?zāi)Ｐ?，也是廣泛應(yīng)用于尋找抗覓藥行為的有效工具。該實(shí)驗(yàn)將實(shí)驗(yàn)動(dòng)物（大鼠、小鼠）置于條件性位置偏愛(ài)箱的白色觀(guān)察區(qū)，并給予精神依賴(lài)性藥物（例如*），然后觀(guān)察實(shí)驗(yàn)動(dòng)物在條件性位置偏愛(ài)箱的黑色區(qū)和白色區(qū)的活動(dòng)情況，白色區(qū)、黑色區(qū)以及其中的灰色 區(qū)之間有小門(mén)可供動(dòng)物自由穿梭。動(dòng)物每次處于給藥區(qū)就會(huì)在藥物獎(jiǎng)賞性效應(yīng)的作用下對(duì)黑色和白色區(qū)域產(chǎn)生位置上的偏好，其程度與藥物的精神依賴(lài)性相關(guān)。

9.   懸尾

懸尾實(shí)驗(yàn)主要用于抗抑郁、鎮(zhèn)靜以及止痛類(lèi)藥物的研究。懸尾實(shí)驗(yàn)系統(tǒng)適用于大鼠、小鼠或其他實(shí)驗(yàn)室動(dòng)物，通過(guò)固定動(dòng)物尾部使其頭向下懸掛，記錄處于該環(huán)境的動(dòng)物產(chǎn)生絕望的不動(dòng)狀態(tài)過(guò)程中的一系列參數(shù)。

10. 條件性恐懼實(shí)驗(yàn)（fear conditioning）

條件性恐懼分析用于小型嚙齒類(lèi)動(dòng)物（大、小鼠）環(huán)境相關(guān)條件性恐懼實(shí)驗(yàn)研究。抗抑郁藥和抗中樞興奮藥可以明顯縮短不動(dòng)狀態(tài)持續(xù)的時(shí)間。實(shí)驗(yàn)過(guò)程中，實(shí)驗(yàn)對(duì)象被給與一個(gè)聲音信號(hào)，隨后給予電擊刺激。該訓(xùn)練稱(chēng)為條件性訓(xùn)練，訓(xùn)練結(jié)束后實(shí)驗(yàn)動(dòng)物進(jìn)行聲音信號(hào)或環(huán)境性實(shí)驗(yàn)。一般情況下嚙齒類(lèi)動(dòng)物對(duì)相應(yīng)的環(huán)境和不同環(huán)境下同樣的聲音信號(hào)都會(huì)做出明顯的條件性恐懼反應(yīng)，如靜止不動(dòng)。

11. 震驚條件反射（startle and pre-pulse inhibition）

      12．新穎物體識(shí)別（novel object recognition）

      The subject is habituated to the test chamber and allowed to freely explore for a set time.   A novel object is placed in one of the two enclosures, and the percentage of time the mouse spends in the section with the new object is compared to the time spent in the section with the empty enclosure.   In a later session, the time spent with the same object might be compared to time spent with a newer, more novel object.